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Smith Collection | Archive Photos | Getty ImagesPfizer on Tuesday said its experimental obesity drug, which it acquired through Metsera, drove solid weight loss when taken once a month in a mid-stage trial. Patients with obesity or who are overweight lost up to 12.3% of their weight compared with placebo at week 28 in the ongoing phase two study. The injection’s weight loss was up to 10.5% when analyzing all patients regardless of discontinuations.The company said no plateau was observed after patients transitioned to monthly dosing, which suggests that continued weight loss is expected as the study continues through week…

Pfizer on Tuesday reported fourth-quarter results that topped estimates even amid dwindling demand for its Covid products, while reaffirming its modest 2026 guidance that rattled investors in December.The pharmaceutical giant is looking to longer-term investments in its pipeline, including its $10 billion acquisition of the obesity biotech Metsera, to counter waning Covid product sales and declines from older drugs. Pfizer moved to show the promise of that investment Tuesday, when it also reported mid-stage data showing that an obesity injection from Metsera can be taken once a month and drive solid weight loss. In addition, Pfizer is on track to…

Merck on Tuesday reported fourth-quarter earnings and revenue that topped estimates on strong demand for its cancer immunotherapy Keytruda and some newer products. But the company posted a modest 2026 outlook that fell short of Wall Street’s expectations as it prepares for a few drugs to lose patent protection later this year and face generic competition. That includes Type 2 diabetes drugs, Januvia and Janumet, and Bridion, a treatment that helps restore muscle function that was blocked during surgery. While those medicines aren’t top-selling products like Keytruda, their combined lower sales will likely pressure the company. The pharmaceutical giant anticipates its 2026 revenue…

Packages of Pepsi are displayed on a store shelf on Oct. 9, 2025 in San Anselmo, California. Justin Sullivan | Getty ImagesPepsiCo on Tuesday reported quarterly earnings and revenue that topped analysts’ expectations, fueled by improving organic sales across its business.Shares of the food and beverage giant fell more than 1% in premarket trading.Here’s what the company reported compared with what Wall Street was expecting, based on a survey of analysts by LSEG:Earnings per share: $2.26 adjusted vs. $2.24 expectedRevenue: $29.34 billion vs. $28.97 billion expectedPepsi reported fourth-quarter net income attributable to the company of $2.54 billion, or $1.85 per share, up from…

Bracha Cohen knows that she actually cannot do it all, or at least not all at once.A partner within asset and wealth management engineering at Goldman Sachs, Cohen said that knowing how to delegate responsibility is crucial to excelling in her job while raising seven children.”Does this need to be me directly, or is this the kind of thing that a delegate could do just as well, and it won’t compromise the outcome?” Cohen, who has been at Goldman for more than three decades and climbed to its upper echelons as a partner, said.Around one in four employees at Goldman…

This as-told-to essay is based on a conversation with Nabil Bukhari, the Seattle-based president of AI platforms and chief technology officer at AI-powered cloud-networking company Extreme Networks. The following has been edited for length and clarity.I wear multiple hats at Extreme Networks, a company with roughly 3,000 employees. I’m the president of the AI business, own the product portfolio, and serve as the CTO.The decision to create an AI clone of myself started as a joke. My team was talking about how we have to sit through all of these meetings and saying, “I wish we could be in more…

After nearly a decade of working as a software engineer, Harshita Pal quit her well-paying job at an American multi-national retailer to pursue a completely different path: product management.Despite earning her bachelor’s degree in electronics and communications engineering in 2013 and working her way up to senior and lead roles within the field, Pal decided in 2021 to make what she called a “thoughtful pivot.” The pivot involved getting her MBA, learning a completely new skill set, and landing an internship at a Big Tech company.The risk paid off; today, 33-year-old Pal is a senior product manager at the same…

Kilmar Abrego Garcia enters a U.S. Immigration and Customs Enforcement field office in August 2025 in Baltimore after he was returned to the U.S. from El Salvador. Anna Moneymaker/Getty Images hide caption toggle caption Anna Moneymaker/Getty Images The case of Kilmar Abrego Garcia captured national headlines last year as part of a wave of criticism against the second Trump administration’s aggressive immigration enforcement. It was the speed of his deportation — from working in Maryland one week, to getting whisked off to a notorious prison in El Salvador the next. But it was also because it was a mistake: something…

Students cheer during a school walkout to protest federal immigration enforcement at the State Capitol building on January 14, 2026, in St. Paul, Minnesota. Stephen Maturen/Getty Images North America hide caption toggle caption Stephen Maturen/Getty Images North America The deaths of Renee Macklin Good and Alex Pretti have shaken up the conversation about how states should respond to immigration crackdowns across the country. Some Democratic leaders have vowed to hold federal Immigration and Customs Enforcement officers accountable — even charging them with crimes. After an ICE surge in Chicago last year, state leaders established the Illinois Accountability Commission to collect…

A document that was included in the Department of Justice release of the Jeffrey Epstein files, photographed Monday, shows a diagram prepared by the FBI attempting to chart the network of Epstein’s victims and the timeline of their alleged abuse. Jon Elswick/AP hide caption toggle caption Jon Elswick/AP The release of millions of pages of Epstein files Friday has raised more questions than it has answered. Convicted sex offender Jeffrey Epstein’s private communications continue to reveal the web of powerful figures who sought his friendship and counsel. Internal notes from the Justice Department show the extent of allegations made against…